Events & Media

The Bren School of Environmental Science & Management
at the University of California, Santa Barbara



"Reformulation Strategies in Designing Drug Delivery Systems
and their Toxicological Assessments"

Joachim Loo
Associate Professor
School of Materials Science and Engineering
Nanyang Technological University

Wednesday, June 27, 2012
11:00 - 12:00 a.m.
Bren Hall 2436 - Dean's Conference Room

“Dr. Loo is researching novel applications of nanomaterials in medicine, which are an example of a proposed beneficial application of nanotechnology for society." — Patricia Holden, faculty host

Particulate systems have been extensively used in the delivery of drugs. However, monolithic or single-layered polymeric particles may suffer from several inherent limitations, including initial burst release of drugs, a lack of time-delayed or pulsatile release of drugs, and the inability to achieve constant drug release. The development of particulate systems using multi-layered (from double-layered to quadruple-layered, and potentially multilayered) particles with layer localization of drugs can be achieved through a simple, direct, and economical one-step fabrication technique. Multi-layered particles possess unique structural attributes, thus offering greater versatility in controlling the drug-release kinetics and profiles. This presentation will explain the use of this one-step technique in fabricating multi-layered particles as carriers of multiple drugs. A novel delivery system that allows for the encapsulation of drug-loaded nanoparticles within a microcapsule will also be presented. The uniqueness of these systems for the delivery of multiple drug entities, while overcoming burst release, will be discussed. At the same time, the toxicological assessments of nanomaterials will also be reviewed.

Joachim Loo received his PhD from Nanyang Technological University (NTU) and was a visiting scientist at the Mayo Clinic in Minnesota before returning as an NTU tenured-track faculty staff in 2006. His research interests include controlled drug-delivery particulate systems, Drug-Eluting Balloons (DEB), and nanotoxicology. He had published approximately sixty international peer-reviewed journal paper and one book chapter, and has filed seven US patents in these research areas. He has served as a reviewer for a number of premier journals, and is on the International Editorial Review Board for the International Journal of Biomaterials Research and Engineering (IJBRE). He has been an invited speaker at several international conferences, and as a guest of multinational corporations, such as 3M, and serves as a consultant to several local and international. He has received awards for research, teaching, and administration, including the Outstanding Mentor Award and the Teaching Excellence Award (2011), and the Service Recognition Award (2010). He is also the program manager of the Solar Energy and Solar Fuel Centre under the Energy Research Institute at NTU), and the chief principal investigator/director of the NTU Solar Fuels Laboratory. Dr. Loo is also currently serving as secretary of the Materials Research Society of Singapore (MRS-S), and is a member of the American Nano Society and the ISO/TC 229 Nanotechnology National Working Group.

NOTE: Research colloquia are hosted by Bren faculty members and are generally high-level talks about research in a particular area of environmental science and management.


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